Gene sequences and enzyme sequences in biosynthetic pathways
Tryptophan metabolism in Salmonella
It has been earlier shown that for tryptophan synthesis in Salmonella, five enzymes are needed for five steps earlier described as 1, 2, 3, 4, 5. It was found that the genes for three enzymes in Salmonella are found in the same order in which the steps are found in the biosynthetic pathway.
More than 500 mutations for histidine metabolism in Salmonella were mapped. These were linked in nine closely linked loci A to H, each affecting a different enzyme in the synthesis of histidine. The gene sequence was found to follow largely the metabolic sequence.
For several other traits including proline, threonine and isoleucine - valine metabolism in Salmonella, a similar clustering of genes was observed. This suggests, that at a primitive stage biochemical synthesis during evolution must have first organized on the chromosome itself.
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