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  Section: Molecular Biology of Plant Pathways » Engineering Formation of Medicinal Compounds in Cell Cultures
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Allen, R. S., Millgate, A. G., Chitty, J. A., Thisleton, J., Miller, J. A., Fist, A. J., Gerlach, W. L., and Larkin, P. J. (2004). RNAi-mediated replacement of morphine with the nonnarcotic alkaloid reticuline in opium poppy. Nat. Biotechnol. 22, 1559–1566.

Askin, I., Ribnicky, D. M., Komarnytsky, S., Ilic, N., Poulev, A., Borisjuk, N., Brinker, A., Moreno, D. A., Ripoll, C., Yakoby, N., O’Neal, J. M., Cornwell, T., et al. (2002). Plants and human health in the twenty-first century. Trends Biotechnol. 20, 522–531.

Bird, D. A., Franceschi, V. R., and Facchini, P. J. (2003). A tale of three cell-types: Alkaloid biosynthesis is localized to sieve elements in opium poppy. Plant Cell 15, 2626–2635.

Bisaria, V., and Panda, A. (1991). Large-scale plant cell culture: Methods, applications and products. Curr. Opin. Biotechnol. 2, 370–374.

Bock, A., Wanner, G., and Zenk, M. H. (2002). Immunocytological localization of two enzymes involved in berberine biosynthesis. Planta 216, 57–63.

Borevitz, J. O., Xia, Y. J., Blount, J., Dixon, R. A., and Lamb, C. (2000). Activation tagging identifies a conserved MYB regulator of phenylpropanoid biosynthesis. Plant Cell 12, 2383–2393.

Briskin, D. P. (2000). Medicinal plants and phytomedicines. Linking plant biochemistry and physiology to human health. Plant Physiol. 124, 507–514.

Burger, C., Rondet, S., Benveniste, P., and Schaller, H. (2003). Virus-induced silencing of sterol biosynthetic genes: Identification of a Nicotiana tabacum L. obtusifoliol-14 alpha-demethylase (CYP51) by genetic manipulation of the sterol biosynthetic pathway in Nicotiana benthamiana L. J. Exp. Bot. 54, 1675–1683.

Burlat, V., Oudin, A., Courtois, M., Rideau, M., and St.-Pierre, B. (2004). Co-expression of three MEP pathway genes and geraniol 10-hydroxylase in internal phloem parenchyma of Catharanthus roseus implicates multicellular translocation of intermediates during the biosynthesis of monoterpene indole alkaloids and isoprenoid-derived primary metabolites. Plant J. 38, 131–141.

Canel, C., Lopes-Cardoso, M. I., Whitmer, S., Van der Fits, L., Pasquali, G., Van Der Heijden, R., Hoge, J. H., and Verpoorte, R. (1998). Effects of over-expression of strictosidine synthase and tryptophan decarboxylase on alkaloid production by cell cultures of Catharanthus roseus. Planta 205, 414–419.

Chatel, G., Montiel, G., Pre, M., Memelink, J., Thiersault, M., Saint-Pierre, B., Doireau, P., and Gantet, P. (2003). CrMYC1, a Catharanthus roseus elicitor- and jasmonate-responsive bHLH factor that binds the G-box element of the strictosidine synthase gene promoter. J. Exp. Bot. 54, 2587–2588.

Choi, K. B., Morishige, T., Shitan, N., Yazaki, K., and Sato, F. (2002). Molecular cloning and characterization of coclaurine N-methyltransferase from cultured cells of Coptis japonica. J. Biol. Chem. 277, 830–835.

Collu, G., Unver, N., Peltenburg-Looman, A. M., Van Der Heijden, R., Verpoorte, R., and Memelink, J. (2001). Geraniol 10-hydroxylase, a cytochrome P450 enzyme involved in terpenoid indole alkaloid biosynthesis. FEBS Lett. 508, 215–220.

Contin, A., Van Der Heijden, R., Lefeber, A. W., and Verpoorte, R. (1998). The iridoid glucoside secologanin is derived from the novel triose phosphate/pyruvate pathway in a Catharanthus roseus cell culture. FEBS Lett. 434, 413–416.

Croteau, R., Kutchan, T. M., and Lewis, N. G. (2000). Natural products (Secondary metabolites). In ‘‘Biochemistry & Molecular Biology of Plants’’ (B. B. Buchanan, W. Gruissem, and R. L. Jones, eds.), pp. 1250–1318. American Society of Plant Physiologists, Maryland.

Curtis, W. R. (1993). Cultivation of roots in bioreactors. Curr. Opin. Biotechnol. 4, 205–210.

Decker, G., Wanner, G., Zenk, M. H., and Lottspeich, F. (2000). Characterization of proteins in latex of the opium poppy (Papaver somniferum) using two-dimensional gel electrophoresis and microsequencing. Electrophoresis 21, 3500–3516.

De Luca, V., and Laflamme, P. (2001). The expanding universe of alkaloid biosynthesis. Curr. Opin. Plant Biol. 4, 225–233.

De Luca, V., Marineau, C., and Brisson, N. (1989). Molecular cloning and analysis of cDNA encoding a plant tryptophan decarboxylase: Comparison with animal dopa decarboxylases. Proc. Natl. Acad. Sci. USA 86, 2582–2586.

Deus-Neumann, B., and Zenk, M. H. (1984). Instability of indole alkaloid production in Catharanthus roseus cell suspension cultures. Planta Med. 50, 427–431.

Dittrich, H., and Kutchan, T. M. (1991). Molecular cloning, expression, and induction of berberine bridge enzyme, an enzyme essential to the formation of benzophenanthridine alkaloids in the response of plants to pathogen attack. Proc. Natl. Acad. Sci. USA 88, 9969–9973.

Dougall, D. K. (1981). Tissue culture and the study of secondary (natural) products. In ‘‘The Biochemistry of Plants’’ (E. E. Conn, ed.), Vol. 7, pp. 21–34. Academic Press, New York.

Eilert, U., De Luca, V., Constabel, F., and Kurz, W. G. (1987). Elicitor-mediated induction of tryptophan decarboxylase and strictosidine synthase activities in cell suspension cultures of Catharanthus roseus. Arch. Biochem. Biophys. 254, 491–497.

Facchini, P. (2001). Alkaloid biosynthesis in plants: Biochemistry, cell biology, molecular regulation, and metabolic engineering applications. Annu. Rev. Plant Physiol. Plant Mol. Biol. 52, 29–66.

Facchini, P. J., and De Luca, V. (1994). Differential and tissue-specific expression of a gene family for tyrosine/dopa decarboxylase in opium poppy. J. Biol. Chem. 269, 26684–26690.

Facchini, P. J., and De Luca, V. (1995). Phloem-specific expression of tyrosine/dopa decarboxylase genes and the biosynthesis of isoquinoline alkaloids in opium poppy. Plant Cell 7, 1811–1821.

Facchini, P. J., and Park, S. U. (2003). Developmental and inducible accumulation of gene transcripts involved in alkaloid biosynthesis in opium poppy. Phytochemistry 64, 177–186.

Facchini, P. J., and St-Pierre, B. (2005). Synthesis and trafficking of alkaloid biosynthetic enzymes. Curr. Opin. Plant Biol. 8, 657–666.

Frick, S., and Kutchan, T. M. (1999). Molecular cloning and functional expression of O-methyltransferases common to isoquinoline alkaloid and phenylpropanoid biosynthesis. Plant J. 17, 329–339.

Frick, S., Chitty, J. A., Karamell, R., Schumidt, J., Allen, R. S., Larkin, P. J., and Kutchan, T. M. (2004). Transformation of opium poppy (Papaver somniferum L.) with antisense berberine bridge enzyme gene (anti-bbe) via somatic embryogenesis results in an altered ratio of alkaloids in latex but not in roots. Transgenic Res. 13, 607–613.

Fu, T.-J. (1998). Safety considerations for food ingredients produced by plant cell and tissue culture. Chemtech 28, 40–46.

Fujii, N., Inui, T., Iwasa, K., Morishige, T., and Sato, F. (2007). Knockdown of berberine bridge enzyme by RNAi accumulates (S)-reticuline and activates a silent pathway in cultured California poppy cells. Transgenic Research 16, 363–375.

Fujita, Y., Suga, C., Matsubara, K., and Hara, Y. (1986). Production of shikonin derivatives by plant-cell cultures. Nippon Nogeikagaku Kaishi 60, 849–854 (in Japanese).

Galbraith, D. W., Harkins, K. R., and Knapp, S. (1991). Systemic endopolyploidy in Arabidopsis thaliana. Plant Physiol. 96, 985–989.

Galneder, E., Rueffer, M., Wanner, G., Tabata, M., and Zenk, M. H. (1988). Alternative final steps in berberine biosynthesis in Coptis japonica cell cultures. Plant Cell Rep. 7, 1–4.

Geerlings, A., Martinez-Lozano, M., Memelink, J., Van Der Heijden, R., and Verpoorte, R. (2000). Molecular cloning and analysis of strictosidine β-D-glucosidase, an enzyme in terpenoid indole alkaloid biosynthesis in Catharanthus roseus. J. Biol. Chem. 275, 3051–3056.

Goddijn, O. J., De Kam, R. J., Zanetti, A., Schilperoort, R. A., and Hoge, J. H. (1992). Auxin rapidly down-regulates transcription of the tryptophan decarboxylase gene from Catharanthus roseus. Plant Mol. Biol. 18, 1113–1120.

Goossens, A., Haekkinen, S. T., Laakso, I., Oksman-Caldentey, O.-M., and Inze, D. (2003a). Secretion of secondary metabolites by ATP-binding cassette transporters in plant cell suspension cultures. Plant Physiol. 131, 1161–1164.

Goossens, A., Haekkinen, S. T., Laakso, I., Seppaenen-Laakso, T., Biondi, S., De Sutter, V., Lammertyn, F., Nuutila, A. M., Soederlund, H., Zabeau, M., Inze, D., and Oksman-Caldentey, K.-M. (2003b).

A functional genomics approach toward the understanding of secondary metabolism in plant cells. Proc. Natl. Acad. Sci. USA 100, 8595–8600.

Grothe, T., Lenz, R., and Kutchan, T. M. (2001). Molecular characterization of the salutaridinol-7-Oacetyltransferase involved in morphine biosynthesis in opium poppy Papaver somniferum. J. Biol. Chem. 276, 30717–30723.

Gundlach, H., Mueller, M., Kutchan, T. M., and Zenk, M. H. (1992). Jasmonic acid is a signal transducer in elicitor-induced plant cell cultures. Proc. Natl. Acad. Sci. USA 89, 2389–2393.

Hashimoto, T., and Yamada, Y. (2003). New genes in alkaloid metabolism and transport. Curr. Opin. Biotechnol. 14, 163–168.

Hashimoto, T., Yukimune, Y., and Yamada, Y. (1986). Tropane alkaloid production in Hyoscyamus root cultures. J. Plant Physiol. 124, 61–76.

Hashimoto, T., Hayashi, A., Amano, Y., Kohno, J., Iwanari, H., Usuda, S., and Yamada, Y. (1991). Hyoscyamine 6 β-hydroxylase, an enzyme involved in tropane alkaloid biosynthesis, is localized at the pericycle of the root. J. Biol. Chem. 266, 4648–4653.

Hauschild, K., Pauli, H. H., and Kutchan, T. M. (1998). Isolation and analysis of a gene bbe1 encoding the berberine bridge enzyme from the California poppy Eschscholzia californica. Plant Mol. Biol. 36, 473–478.

Hibi, N., Higashiguchi, S., Hashimoto, T., and Yamada, Y. (1994). Gene expression in tobacco lownicotine mutants. Plant Cell 6, 723–735.

Hirochika, H., Sugimoto, K., Otsuki, Y., Tsugawa, H., and Kanda, M. (1996). Retrotransposons of rice involved in mutations induced by tissue culture. Proc. Natl. Acad. Sci. USA 93, 7783–7788.

Honda, Y., Inaoka, H., Takei, A., Sugimura, Y., and Otsuji, K. (1996). Extracellular polysaccharides produced by tuberose callus. Phytochemistry 41, 1517–1521.

Huang, F.-C., and Kutchan, T. M. (2000). Distribution of morphinan and benzo[c]phenanthridine alkaloid gene transcript accumulation in Papaver somniferum. Phytochemistry 53, 555–564.

Ikezawa, N., Tanaka, M., Nagayoshi, M., Shinkyo, R., Sakaki, T., Inouye, K., and Sato, F. (2003). Molecular cloning and characterization of CYP719, a methylenedioxy bridge-forming enzyme that belongs to a novel P450 family, from cultured Coptis japonica cells. J. Biol. Chem. 278, 38557–38565.

Ikezawa, N., Iwasa, K., and Sato, F. (2007). Molecular cloning and characterization of methylenedioxy bridge-forming enzymes involved in stylopine biosynthesis in Eschscholzia californica. FEBS J. 274, 1019–1035.

Irmler, S., Schroeder, G., St-Pierre, B., Crouch, N. P., Hotze, M., Schmidt, J., Strack, D., Matern, U., and Schroeder, J. (2000). Indole alkaloid biosynthesis in Catharanthus roseus: New enzyme activities and identification of cytochrome P450 CYP72A1 as secologanin synthase. Plant J. 24, 797–804.

Ishihara, S., Yamamoto, Y., Ifuku, K., and Sato, F. (2005). Functional analysis of four members of the PsbP family in photosystem II in Nicotiana tabacum using differential RNA interference. Plant Cell Physiol. 46, 1885–1893.

Jennewein, S., and Croteau, R. (2001). Taxol: Biosynthesis, molecular genetics, and biotechnological applications. Appl. Microbiol. Biotechnol. 57, 13–19.

Kanegae, T., Kajiya, H., Amano, Y., Hashimoto, T., and Yamada, Y. (1994). Species-dependent expression of the hyoscyamine 6-β-hydroxylase gene in the pericycle. Plant Physiol. 105, 483–490.

Ketchum, R. E., Rithner, C. D., Qiu, D., Kim, Y. S., Williams, R. M., and Croteau, R. B. (2003). Taxus metabolomics: Methyl jasmonate preferentially induces production of taxoids oxygenated at C-13 in Taxus x media cell cultures. Phytochemistry 62, 901–909.

Kraus, P. F. X., and Kutchan, T. M. (1995). Molecular-cloning and heterologous expression of a cDNAencoding berbamunine synthase, a C-O-phenol-coupling cytochrome-P450 from the higher-plant Berberis-stolonifera. Proc. Natl. Acad. Sci. USA 92(6), 2071–2075.

Kusakari, K., Yokoyama, M., and Inomata, S. (2000). Enhanced production of saikosaponins by root culture of Bupleurum falcatum L. using two-step control of sugar concentration. Plant Cell Rep. 19, 1115–1120.

Kutchan, T. M. (2005a). A role for intra-and intercellular translocation in natural product biosynthesis. Curr. Opin. Plant Biol. 8, 292–300.

Kutchan, T. M. (2005b). Predictive metabolic engineering in plants: Still full of surprises. Trends Biotechnol. 23, 381–383.

Kutchan, T. M., Hampp, N., Lottspeich, F., Beyreuther, K., and Zenk, M. H. (1988). The cDNA clone for strictosidine synthase from Rauvolfia serpentina: DNA sequence determination and expression in Escherichia coli. FEBS Lett. 237, 40–44.

Lange, B. M., and Croteau, R. (1999). Genetic engineering of essential oil production in mint. Curr. Opin. Plant Biol. 2, 139–144.

Lange, B. M., Wildung, M. R., Stauber, E. J., Sanchez, C., Pouchnik, D., and Croteau, R. (2000). Probing essential oil biosynthesis and secretion by functional evaluation of expressed sequence tags from mint glandular trichomes. Proc. Natl. Acad. Sci. USA 97, 2934–2939.

Liscombe, D. K., Macleod, B. P., Loukanina, N., Nandi, O. I., and Facchini, P. J. (2005). Evidence for the monophyletic evolution of benzylisoquinoline alkaloid biosynthesis in angiosperms. Phytochemistry 66, 1374–1393.

Lloyd, A. M., Walbot, V., and Davis, R. W. (1992). Arabidopsis and Nicotiana anthocyanin production activated by maize regulator-R and regulator-C1. Science 258, 1773–1775.

Lopez-Meyer, M., and Nessler, C. L. (1997). Tryptophan decarboxylase is encoded by two autonomously regulated genes in Camptotheca acuminata which are differentially expressed during development and stress. Plant J. 11, 1167–1175.

Lorenzo, O., Piqueras, R., Sanchez-Serrano, J. J., and Solano, R. (2003). Ethylene response factor1 integrates signals from ethylene and jasmonate pathways in plant defense. Plant Cell 15, 165–178.

Mahmoud, S. S., and Croteau, R. B. (2001). Metabolic engineering of essential oil yield and composition in mint by altering expression of deoxyxylulose phosphate reductoisomerase and menthofuran synthase. Proc. Natl. Acad. Sci. USA 98, 8915–8920.

Mahmoud, S. S., and Croteau, R. B. (2002). Strategies for transgenic manipulation of monoterpene biosynthesis in plants. Trends Plant Sci. 7, 366–373.

Matsubara, K., Kitani, S., Yoshioka, T., Morimoto, T., and Fujita, Y. (1989). High-density culture of Coptis japonica cells increases berberine production. J. Chem. Technol. Biotechnol. 46, 61–69.

Matsuda, J., Okabe, S., Hashimoto, T., and Yamada, Y. (1991). Molecular cloning of hyoscyamine 6 b-hydroxylase, a 2-oxoglutarate-dependent dioxygenase, from cultured roots of Hyoscyamus niger. J. Biol. Chem. 266, 9460–9464.

Mcknight, T. D., Toessner, C. A., Devagupta, R., Scott, A. I., and Nessler, C. L. (1990). Nucleotide sequence of a cDNA encoding the vacuolar protein strictosidine synthase from Catharanthus roseus. Nucleic Acids Res. 18, 4939.

Millgate, A. G., Pogson, B. J., Wilson, I. W., Kutchan, T. M., Zenk, M. H., Gerlach, W. L., Fist, A. J., and Larkin, P. J. (2004). Morphine-pathway block in top1 poppies. Nature 431, 413–414.

Minami, H., Dubouzet, E., Iwasa, K., and Sato, F. (2007). Functional analysis of norcoclaurine synthase in Coptis japonica, J. Biol. Chem. 282, 6274–6282.

Misawa, M. (1994). Plant tissue culture: An alternative for production of useful metabolite. FAO AGRICULTURAL SERVICES BULLETIN No. 108, M-06, ISBN 92–5-103391–9, http://www.fao. org/docrep/t0831e/t0831e00.htm#con.

Morishige, T., Tsujita, T., Yamada, Y., and Sato, F. (2000). Molecular characterization of the S-adenosyl- L-methionine: 30-hydroxyl-N-methylcoclaurine 40-O-methyltransferase involved in isoquinoline alkaloid biosynthesis in Coptis japonica. J. Biol. Chem. 275, 23398–23405.

Morishige, T., Dubouzet, E., Choi, K. B., Yazaki, K., and Sato, F. (2002). Molecular cloning of columbamine O-methyltransferase from cultured Coptis japonica cells. Eur. J. Biochem. 269, 5659–5667.

Muemmler, S., Rueffer, M., Nagakura, N., and Zenk, M. H. (1985). S-Adenosyl-L-methionine: (S)-scoulerine 9-O- methyltransferase, a highly stereo- and regio-specific enzyme in tertrahydroprotoberberine biosynthesis. Plant Cell Rep. 4, 36–39.

Nakajima, K., and Hashimoto, T. (1999). Two tropinone reductases, that catalyze opposite stereospecific reductions in tropane alkaloid biosynthesis, are localized in plant root with different cell-specific patterns. Plant Cell Physiol. 40, 1099–1107.

Nakajima, K., Hashimoto, T., and Yamada, Y. (1993). Two tropinone reductases with different stereospecificities are short-chain dehydrogenases evolved from a common ancestor. Proc. Natl. Acad. Sci. USA 90, 9591–9595.

Nelson, D. R., Schuler, M. A., Paquette, S. M., Werck-Reichhart, D., and Bak, S. (2004). Comparative genomics of rice and Arabidopsis. Analysis of 727 cytochrome P450 genes and psuedogenes from a monocot and a dicot. Plant Physiol. 135, 756–772.

O’Keefe, B. R., Mahady, G. B., Gills, J. J., Beecher, C. W. W., and Schilling, A. B. (1997). Stable vindoline production in transformed cell cultures of Catharanthus roseus. J. Nat. Prod. 60, 261–264.

Oksman-Caldentey, K. M. (2002). Agrobacterium rhizogenes-mediated transformation: Root cultures as a source of alkaloids. Planta Med. 68, 859–868.

Park, S. U., and Facchini, P. J. (2000). Agrobacterium rhizogenes- mediated transformation of opium poppy, Papaver somniferum I., and California poppy, Eschscholzia californica cham., root cultures. J. Exp. Bot. 51, 1005–1016.

Park, S. U., Johnson, A. G., Penzes-Yost, C., and Facchini, P. J. (1999). Analysis of promoters from tyrosine/dihydroxyphenylalanine decarboxylase and berberine bridge enzyme genes involved in benzylisoquinoline alkaloid biosynthesis in opium. Plant Mol. Biol. 40, 121–131.

Park, S. U., Yu, M., and Facchini, P. J. (2002). Antisense RNA-mediated suppression of benzophenanthridine alkaloid biosynthesis in transgenic cell cultures of California poppy. Plant Physiol. 128, 696–706.

Pauli, H. H., and Kutchan, T. M. (1998). Molecular cloning and functional heterologous expression of two alleles encoding (S)-N-methylcoclaurine 3'-hydroxylase (CYP80B1), a new methyl jasmonateinducible cytochrome P-450-dependent mono-oxygenase of benzylisoquinoline alkaloid biosynthesis. Plant J. 13, 793–801.

Petersen, M., and Alfermann, A. W. (2001). The production of cytotoxic lignans by plant cell cultures. Appl. Microbiol. Biotechnol. 55, 135–142.

Phillips, R. L., Kaeppler, S. M., and Olhoft, P. (1994). Genetic instability of plant tissue cultures: Breakdown of normal controls. Proc. Natl. Acad. Sci. USA 91, 5222–5226.

Rathbone, D. A., and Bruce, N. C. (2002). Microbial transformation of alkaloids. Curr. Opin. Microbiol. 5, 274–281.
Sakai, K., Shitan, N., Sato, F., Ueda, K., and Yazaki, K. (2002). Characterization of berberine transport into Coptis japonica cells and the involvement of ABC protein. J. Exp. Bot. 53, 1879–1886.

Samanani, N., and Facchini, P. J. (2002). Purification and characterization of norcoclaurine synthase. J. Biol. Chem. 277, 33878–33883.

Samanani, N., Liscombe, D. K., and Facchini, P. J. (2004). Molecular cloning and characterization of norcoclaurine synthase, an enzyme catalyzing the first committed step in benzylisoquinoline alkaloid biosynthesis. Plant J. 40, 302–313.

Samanani, N., Park, S.-U., and Facchini, P. J. (2005). Cell type-specific localization of transcripts encoding nine consecutive enzymes involved in protoberberine alkaloid biosynthesis. Plant Cell 17, 915–926.

Sasaki, T., Song, J., Koga-Ban, Y., Matsui, E., Fang, F., Higo, H., Nagasaki, H., Hori, M., Miya, M., Murayama-Kayano, E., Takiguchi, T., Takasuga, A., et al. (1994). Toward cataloguing all rice genes: Large-scale sequencing of randomly chosen rice cDNAs froma callus cDNAlibrary. Plant J. 6, 615–624.

Sato, F., and Yamada, Y. (1984). High berberine-producing cultures of Coptis japonica cells. Phytochemistry 23, 281–285.

Sato, F., Hashimoto, T., Hachiya, A., Tamura, K., Choi, K. B., Morishige, T., Fujimoto, H., and Yamada, Y. (2001). Metabolic engineering of plant alkaloid biosynthesis. Proc. Natl. Acad. Sci. USA 98, 367–372.

Schmeller, T., Latz-Bruning, B., and Wink, M. (1997). Biochemical activities of berberine, palmatine and sanguinarine mediating chemical defence against microorganisms and herbivores. Phytochemistry 44, 257–266.

Scholl, Y., Schneider, B., and Drager, B. (2003). Biosynthesis of calystegines: 15N NMR and kinetics of formation in root cultures of Calystegia sepium. Phytochemistry 62, 325–332.

Schroeder, G., Unterbusch, E., Kaltenbach, M., Schmidt, J., Strack, D., De Luca, V., and Schroder, J. (1999). Light-induced cytochrome P450-dependent enzyme in indole alkaloid biosynthesis: Tabersonine 16-hydroxylase. FEBS Lett. 458, 97–102.

Shanks, J. V., and Morgan, J. (1999). Plant ‘‘hairy root’’ culture. Curr. Opin. Biotechnol. 10, 151–155.

Shitan, N., Bazin, I., Dan, K., Obata, K., Kigawa, K., Ueda, K., Sato, F., Forestier, C., and Yazaki, K. (2003). Involvement of CjMDR1, a plant multidrug-resistance-type ATP-binding cassette protein, in alkaloid transport in Coptis japonica. Proc. Natl. Acad. Sci. USA 100, 751–756.

Shoji, T., Nakajima, K., and Hashimoto, T. (2000). Ethylene suppresses jasmonate-induced gene expression nicotine biosynthesis. Plant Cell Physiol. 41, 1072–1076.

Siberil, Y., Benhamron, S., Memelink, J., Giglioli-Guivarch, N., Thiersault, M., Boisson, B., Doireau, P., and Gantet, P. (2001). Catharanthus roseus G-box binding factors 1 and 2 act as repressors of strictosidine synthase gene expression in cell cultures. Plant Mol. Biol. 45, 477–488.

St-Pierre, B., and De Luca, V. (1995). A cytochrome P-450 monooxygenase catalyzes the first step in the conversion of tabersonine to vindoline in Catharanthus roseus. Plant Physiol. 109, 131–139.

St-Pierre, B., Laflamme, P., Alarco, A. M., and De Luca, V. (1998). The terminal O-acetyltransferase involved in vindoline biosynthesis defines a new class of proteins responsible for coenzyme A-dependent acyltransferase. Plant J. 14, 703–713.

St-Pierre, B., Vazquez-Flota, F. A., and De Luca,V. (1999).Multicellular compartmentation of Catharanthus roseus alkaloid biosynthesis predicts intercellular translocation of a pathway intermediate. Plant Cell 11, 887–900.

Suzuki, K., Yamada, Y., and Hashimoto, T. (1999a). Expression of Atropa belladonna putrescine N-methyltransferase gene in root pericycle. Plant Cell Physiol. 40, 289–297.

Suzuki, K., Yun, D. Y., Chen, X. Y., Yamada, Y., and Hashimoto, T. (1999b). An Atropa belladonna hyoscyamine 6 b-hydroxylase gene is differentially expressed in the root pericycle and anthers. Plant Mol. Biol. 40, 141–152.

Suzuki, M., Nakagawa, K., Fukui, H., and Tabata, M. (1987). Relationship of berberine-producing capability between Thalictrum plants and their tissue cultures. Plant Cell Rep. 6, 260–263.

Takeda, S., Sato, F., Ida, K., and Yamada, Y. (1990). Characterization of polypeptides that accumulate in cultured Nicotiana tabacum cells. Plant Cell Physiol. 31(2), 215–221.

Takeshita, N., Fujiwara, H., Mimura, H., Fitchen, J. H., Yamada, Y., and Sato, F. (1995). Molecular cloning and characterization of S-adenosyl-L-methionine: Scoulerine-9-O-methyltransferase from cultured cells of Coptis japonica. Plant Cell Physiol. 36, 29–36.

Taticek, R. A., Lee, C. W., and Shuler, M. L. (1994). Large-scale insect and plant cell culture. Curr. Opin. Biotechnol. 5, 165–174.

Tepfer, D. A., Goldman, A., Pamboukdjian, N., Maille, M., Lepingle, A., Chevalier, D., Denarie, J., and Rosenberg, C. (1988). A plasmid of Rhizobium meliloti 41 encodes catabolism of two compounds from root exudate of Calystegia sepium. J. Bacteriol. 170, 1153–1161.

Tohge, T., Nishiyama, Y., Hirai, M. Y., Yano, M., Nakajima, J., Awazuhara, M., Inoue, E., Takahashi, H., Goodenovwe, D. B., Kitayama, M., Noji, M., Yamazaki, M., et al. (2005). Functional genomics by integrated analysis of metabolome and transcriptome of Arabidopsis plants over-expressing an MYB transcription factor. Plant J. 42, 218–235.

Unterlinner, B., Lenz, R., and Kutchan, T. M. (1999). Molecular cloning and functional expression of codeinone reductase: The penultimate enzyme in morphine biosynthesis in the opium poppy Papaver somniferum. Plant J. 18, 465–475.

Van Der Fits, L., and Memelink, J. (2000). ORCA3, a jasmonate-responsive transcriptional regulator of plant primary and secondary metabolism. Science 289, 295–297.

Van Der Fits, L., Zhang, H., Menke, F. L. H., Deneka, M., and Memelink, J. (2000). A Catharanthus roseus BPF-1 homologue interacts with an elicitor-responsive region of the secondary metabolite biosynthetic gene Str and is induced by elicitor via a JA-independent signal transduction pathway. Plant Mol. Biol. 44, 675–685.

Vazquez-Flota, F. A., De Carolis, E., Alarco, A. M., and De Luca, V. (1997). Molecular cloning and characterization of deacetoxyvindoline 4-hydroxylase, a 2-oxoglutarate-dependent dioxygenase involved in the biosynthesis of vindoline in Catharanthus roseus (I.) G. Don. Plant Mol. Biol. 34, 935–948.

Vazquez-Flota, F., St-Pierre, B., and De Luca, V. (2000). Light activation of vindoline biosynthesis does not require cytomorphogenesis in Catharanthus roseus seedlings. Phytochemistry 55, 531–536.

Vazquez-Flota, F., De Luca, V., Carrillo-Pech, M., Canto-Flick, A., and De Lourdes Miranda-Ham, M. (2002). Vindoline biosynthesis is transcriptionally blocked in Catharanthus roseus cell suspension cultures. Mol. Biotechnol. 22, 1–8.

Verpoorte, R., and Memelink, J. (2002). Engineering secondary metabolite production in plants. Curr. Opin. Biotechnol. 13, 181–187.

Vom Endt, D., Kijne, J. W., and Memelink, J. (2002). Transcriptional factors controlling plant secondary metabolism: What regulates the regulators? Phytochemistry 61, 107–114.

Wang, E., Wang, R., Deparasis, J., Loughrin, H. H., Gan, S., and Wagner, G. J. (2001). Suppression of a P450 hydroxylase gene in plant trichome glands enhances natural-product-based aphid resistance. Nat. Biotechnol. 19, 371–374.

Wang, M. B., and Waterhouse, P. M. (2002). Application of gene silencing in plants. Curr. Opin. Plant Biol. 5(2), 146–150.

Waterhouse, P. M., and Helliwell, C. A. (2003). Exploring plant genomes by RNA-induced gene silencing. Nat. Rev. Genet. 4, 29–38.

Weckwerth, W., and Fiehn, O. (2002). Can we discover novel pathways using metabolomic analysis? Curr. Opin. Biotechnol. 13, 156–160. Weid, M., Ziegler, J., and Kutchan, T. M. (2004). The roles of latex and the vascular bundle in morphine biosynthesis in the opium poppy, Papaver somniferum. Proc. Natl. Acad. Sci. USA 101, 13957–13962.

Wesley, S. V., Helliwell, C. A., Smith, N. A., Wang, M. B., Rouse, D. T., Liu, Q., Gooding, P. S., Sing, S. P., Abbott, D., Stoutjesdijk, P. A., Robinson, S. P., Gleave, A. P., et al. (2001). Construct design for efficient, effective and high-throughput gene silencing in plants. Plant J. 27, 581–590.

Whitmer, S., Canel, C., Hallard, D., Goncalves, C., and Verpoorte, R. (1998). Influence of precursor availability on alkaloid accumulation by transgenic cell line of Catharanthus roseus. Plant Physiol. 116, 853–857.

Whitmer, S., Canel, C., Van Der Heijden, R., and Verpoorte, R. (2003). Long-term instability of alkaloid production by stably transformed cell lines of Catharanthus roseus. Plant Cell Tissue Organ Cult. 74, 73–80.

Wiermann, R. (1981). Secondary plant products and cell and tissue differentiation. In ‘‘The Biochemistry of Plants’’ (E. E. Conn, ed.), Vol. 7, pp. 85–116. Academic Press, New York.

Winkel-Shirley, B. (2001). Flavonoid biosynthesis. A colorful model for genetics, biochemistry, cell biology, and biotechnology. Plant Physiol. 126(2), 485–493.

Yamada, Y., and Mino, M. (1986). Instability of chromosomes and alkaloid content in cell lines derived from single protoplasts of cultured Coptis japonica cells. Curr. Top. Dev. Biol. 20, 409–417.

Yamazaki, Y., Urano, A., Sudo, H., Kitajima, M., Takayama, H., Yamazaki, M., Aimi, N., and Saito, K. (2003). Metabolite profiling of alkaloids and strictosidine synthase activity in camptothecinproducing plants. Phytochemistry 62, 461–470.

Yamazaki, Y., Kitajima, M., Arita, M., Takayama, H., Sudo, H., Yamazaki, M., Aimi, N., and Saito, K. (2004). Biosynthesis of camptothecin. In silico and in vivo tracer study from [1–13C] glucose. Plant Physiol. 134, 161–170.

Yukimune, Y., Tabata, H., Hara, Y., and Yamada, Y. (1994). Scopolamine yield in cultured roots of Duboisia myoporoides improved by a novel 2-stage culture method. Biosci. Biotechnol. Biochem. 58, 1820–1823.

Yukimune, Y., Tabata, H., Higashi, Y., and Hara, Y. (1996). Methyljasmonate-induced overproduction of paclitaxel and baccatin III in Taxus cell suspension cultures. Nat. Biotechnol. 14, 1129–1132.

Yun, D. J., Hashimoto, T., and Yamada, Y. (1992). Metabolic engineering of medicinal-plants—transgenic Atropa belladonna with an improved alkaloid composition. Proc. Natl. Acad. Sci. USA 89, 11799–11803.

Zhao, J., Davis, L. C., and Verpoorte, R. (2005). Elicitor signal transduction leading to production of plant secondary metabolites. Biotechnol. Adv. 23, 283–333.

Ziegler, J., Diaz-Chavez, M. L., Karamell, R., Ammer, C., and Kutchan, T. M. (2005). Comparative macroarray analysis of morphine containing Papaver somniferum and eight morphine free Papaver species identifies an O-methyltransferase involved in benzylisoquinoline biosynthesis. Planta 222, 458–471.

Zubieta, C., Ross, J. R., Koschesk, I. P., Yang, Y., Pichersky, E., and Noel, J. P. (2003). Structural basis for substrate recognition in the salicylic acid carboxyl methyltransferase family. Plant Cell 15, 1704–1716.

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