Bioinformatics » Pharmacological Relevance

Content

Introduction
Organizing biological knowledge in databases
Analysing sequence data
Structural bioinformatics
Pharmacological Relevance
References
Terms in Bioinformatics

Many aspects of bioinformatics are relevant for pharmacology. Drug targets in infectious organisms can be revealed by whole genome comparisons of infectious and non-infectious organisms. The analysis of single nucleotide polymorphisms reveals genes potentially responsible for genetic deseases. Prediction and analysis of protein 3D structure is used to develop drugs and understand drug resistance.

Patient databases with genetic profiles, e.g. for cardiovascular diseases, diabetes, cancer, etc. may play an important role in the future for individual health care, by integrating personal genetic profile into diagnosis, despite obvious ethical problems. The goal is to analyse a patient's individual genetic profile and compare it with a collection of reference profiles and other related information. This may improve individual diagnosis, prophylaxis, and therapy.