Genetic Engineering for Human Welfare

Vaccines for Rabies Virus (RV)
RV causes hydrophobia in animals and human in many countries like. South America, Africa, Asia (including India and Pakistan). Researches are being done to synthesize vaccines by inducing genetically engineered E. coli cells. However, attempt has been made to isolate mRNA encoding viral protein from RV infected cells. The genes coding for the production of rabies virus glycoprotein coat has been successfully transferred to E. coli. This is the first step towards the production of antirabies virus vaccines as this glycoprotein stimulates antibody production in diseased animals. In 1984, Wistar Institute in Philadelphia developed a new genetically engineered vaccinia virus by inserting a small piece of foreign DNA. The genetically engineered virus synthesized antirabies vaccines for animals. The recombinant vaccinia virus did not cause rabies in those animals that received rabies genome but encoded antigenic molecules and activated the immune system against rabies infection. This new vaccine can be administered orally in animals, and could be decreased the risk of human death due to bites of animals receiving rabies virus (Peters, 1993)
  Content
» Cloned genes and production of chemicals

» Human peptide hormone genes


» Insulines


» Somatotropin


» Somatostatin


» b-endorphin

» Human interferon genes

» Genes for vaccines


» Vaccine for hepatitis-B virus


» Vaccines for Rabies virus


» Vaccines for poliovirus


» Vaccine for foot and mouth disease virus


» Vaccines for small pox virus


» Malaria vaccines


» DNA vaccines

» Genes associated with genetic diseases


» Phenylketonuria


» Urokinase


» Thalassaemia


» Hemophilia

» Enzyme engineering

» Commercial chemicals
» Prevention, diagnosis and cure of diseases

» Prevention of diseases

» Diagnosis of diseases


» Parasitic diseases


» Monoclonal antibodies


» Antenatal diagnosis

» Gene therapy


» Types of gene therapy


» Methods of gene therapy


» Success of gene therapy


» Potential of gene delivering system


» Future needs of gene therapy in India
» DNA profiling (fingerprinting)

» Methods of DNA profiling

» Application of DNA profiling


» Genetic databank


» Reuniting the lost children


» Solving disputed problems of parentage, identity of criminals, rapists, etc


» Immigrant dispute

» Hurdles of DNA profiling
» Animal and plant improvement

» Transgenic Farm Animals

» Crop Improvements


» Transgenic plants


» Nif gene transfer


» Phaseolin gene transfer


» Conversion of C3 plants to C4 plants


» Herbicide resistant plants


» Insect pest resistant plants


» Plant improvement through genetic transformation

» Crop Protection


» Use of antagonists


» Use of insecticides
» Abatement of pollution