Beck, G., and G. S. Habicht. 1996. Immunity
and the invertebrates. Sci. Am. 275:60–66
(Nov.). Invertebrates lack lymphocytes, but
they have cells like macrophages, such as
coelomocytes, and they lack antibodybased
humoral immunity. They have molecules
similar to immunoglobulin, and several
cytokines have been demonstrated,
suggesting precursors for a vertebrate-type
Benjamini, E., G. Sunshine, and S. Leskowitz.
1996. Immunology. A short course, ed. 3.
New York, Wiley-Liss, Inc. An excellent
presentation of the essentials without excessive
Cox, F. E. G., and E. Y. Liew. 1992. T-cell subsets
and cytokines in parasitic infections.
Parasit. Today. 8:371–374. Describes the
interactions of T cells and cytokines in the
TH1 and TH2 arms of the immune response.
Dunn, P. E. 1990. Humoral immunity in insects.
BioScience 40:738–744. There is evidence
that cockroaches are capable of a vertebratelike,
specific, adaptive humoral
Engelhard, V. H. 1994. How cells process antigens.
Sci. Am. 271:54–61. This article
focuses on the roles of the MHC proteins.
Garrett, L. 1995. The coming plague: newly
emerging diseases in a world out of balance.
New York, Penguin Books (orig.
publ. 1994, Farrar, Straus, & Giroux, New
York). As Rachel Carson did with the environment,
Garrett sounds a clarion call on
infectious diseases. New pathogens are
emerging, and familiar ones are developing
multidrug resistance at a time when
transmission favors the microbes: poor sanitation
and increasing crowding in the
world’s cities and impairment of the
immune response in millions of people by
malnutrition and AIDS.
Glausiusz, J. 1999. The chasm in care. Discover 20:40,42. More than 30 million people have
HIV, and nearly 90% live in developing
countries of Asia and sub-Saharan Africa.
There are 16,000 people newly infected
every day. In Zimbabwe, 25% of adult population
Golde, D. W. 1991. The stem cell. Sci. Am. 265:86–93. Undifferentiated cells in bone
marrow give rise to white and red blood
cells, macrophages, and platelets.
Greene, W. C. 1993. AIDS and the immune system.
Sci. Amer. 269:98–105 (Sept.). There
is some evidence that HIV triggers widespread
apoptosis (programmed cell death)
in CD4+ cells.
Karp, R. D. 1990. Cell-mediated immunity in
invertebrates. BioScience 40:732–737. Experiments show that allograft rejection in
insects has at least a short-term memory
component; challenge allografts were
rejected more quickly than third-party allograft
Lichtenstein, L. M. 1993. Allergy and the
immune system. Sci. Am. 269:116–124
(Sept.). Describes what happens in an
allergic response, including the role of mast
cells, basophils, cytokines, and chemical
Mann, J. M., and D. J. M. Tarantola. 1998. HIV
1998: The global picture. Sci. Am. 279:82–83 (July). This is the first of a series
of articles on HIV in this issue. The authors
estimate that more than 40 million people
have contracted HIV since early 1980s.
Two-thirds of all HIV-infected people and
90% of all infected children are in sub-
Marrack, P., and J. W. Kappler. 1993. How the
immune system recognizes the body. Sci.
Am. 269:80–89 (Sept.). Part of the mechanism
by which the immune system tolerates
“self” antigens is by a mechanism known
as clonal deletion.
Paul, W. E. 1993. Infectious diseases and the
immune system. Sci. Am. 269:90–97
(Sept.). Describes the immune response in
certain viral, microbial, and parasitic
Steinman, L. 1993. Autoimmune disease. Sci.
Am. 269:106–114 (Sept.). In five percent of
adults in Europe and North America, the
immune system discrimination between
“self” and “nonself” breaks down, usually
with very serious results.
Strange, C. 1995. Rethinking immunity. Bio-
Science 45:663–668. Some immunologists
believe that the self/nonself dogma of
immunology is inadequate.
Weiss, R. 1994. Of myths and mischief. Discover 15(12):36–42. Debunks the astonishing
myths that have grown up around AIDS,
including the most pernicious of all, that
HIV is not the cause.