Inborn errors in metabolism

Human Genetics
Human chromosomes
Determination of sex
Sex linked inheritance
Chromosomal aberrations
Dizygotic and monozygotic twins
Inborn errors in metabolism
Sickle-cell anaemia
Genetic analysis through pedigree charts
Chromosome mapping in humans (including RFLPs, etc.)
Gene transfer in mammalian cells
Chromosome mediated gene transfer
Transformation of cells with free DNA
Use of human genetics in medical science 
Genetic counseling
Amniocentesis and antenatal diagnosis
Gene therapy
Making a choice of baby's sex
DNA fingerprinting in forensic science
In 1909, A.E. Garrod described certain hereditary diseases which cause certain defects in metabolism. The three diseases, namely (i) alcaptonuria, (ii) phenylketonuria and (iii) albinism result due to block in the metabolism where phenylalanine is broken down and utilized. These were discussed in Mutations : 2.  Biochemical Level (Biochemical and Microbial Genetics) in some detail.