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Genetics » Regulation of Gene Expression » Operon Circuits in Prokaryotes

Regulation by alternative splicing

Content
⇒ Regulation of Gene Expression 1.  Operon Circuits in Bacteria and other Prokaryotes
⇒ Induction and repression
⇒ Inducer and co-repressor
⇒ The operon model for transcriptional regulation 
⇒ The tryptophan operon in bacteria (E. coli and Salmonella)
⇒ Tryptophan (trp) repressor controls three sets of genes
⇒ Negative and Positive Controls of Transcription
⇒ Substitution of Sigma Factor and Control of Transcription
⇒ Multiple sigma factors in E. coli 
⇒ Sporulation in bacteria
⇒ DNA sequences controlling transcription 
⇒ DNA sequences for CAP, RNA polymerase and lac-repressor
⇒ Identification of starting point
⇒ Pribnow box and other sequences common to DNA regions upstream to several operons
⇒ Regulation by DNA rearrangements
⇒ Post-transcriptional regulation
⇒ Leader sequences and attenuators
⇒ Autogenous regulation of translation
⇒ Regulation by alternative splicing
⇒ Regulation by-anti-sense RNA
⇒ Repression and activation of translation
⇒ Feedback inhibition
⇒ Signal transduction and ‘two component regulatory system’
Regulation by alternative splicing
In Expression of Gene : Protein Synthesis 3.  RNA Processing (RNA Splicing, RNA Editing and Ribozymes), we discussed the phenomenon of alternative splicing, which means that a transcript or a precursor mRNA may undergo one of the several paths of alternative splicing, so that the same transcript may lead to the synthesis of different protein 'isoforms' in time and space. This mechanism has been shown to be widespread in organisms ranging from viruses to mammals and is used for regulation of gene expression at the post-transcriptional level. (Consult Expression of Gene : Protein Synthesis 3.  RNA Processing (RNA Splicing, RNA Editing and Ribozymes) for details).


 

 

 

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