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Genetics / Regulation of Gene Expression / Operon Circuits in Prokaryotes

Regulation by alternative splicing

Regulation by alternative splicing
In Expression of Gene : Protein Synthesis 3. RNA Processing (RNA Splicing, RNA Editing and Ribozymes), we discussed the phenomenon of alternative splicing, which means that a transcript or a precursor mRNA may undergo one of the several paths of alternative splicing, so that the same transcript may lead to the synthesis of different protein 'isoforms' in time and space. This mechanism has been shown to be widespread in organisms ranging from viruses to mammals and is used for regulation of gene expression at the post-transcriptional level. (Consult Expression of Gene : Protein Synthesis 3. RNA Processing (RNA Splicing, RNA Editing and Ribozymes) for details).

More in this section

Operon Circuits in Bacteria and other Prokaryotes
Induction and repression
Inducer and co-repressor
The operon model for transcriptional regulation
The tryptophan operon in bacteria (E. coli and Salmonella)
Tryptophan (trp) repressor controls three sets of genes
Negative and Positive Controls of Transcription
Substitution of Sigma Factor and Control of Transcription
Multiple sigma factors in E. coli
Sporulation in bacteria
DNA sequences controlling transcription
DNA sequences for CAP, RNA polymerase and lac-repressor
Identification of starting point
Pribnow box and other sequences common to DNA regions upstream to several operons
Regulation by DNA rearrangements
Post-transcriptional regulation
Leader sequences and attenuators
Autogenous regulation of translation
Regulation by alternative splicing
Regulation by-anti-sense RNA
Repression and activation of translation
Feedback inhibition
Signal transduction and ‘two component regulatory system’

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