Cavenee, W. K., and R. L. White. 1995. The
genetic basis of cancer. Sci. Am. 272:72–79
(Mar.). Describes mutations in cells of colorectal
cancer and brain tumors.
Culotta, D., and D. E. Koshland, Jr. 1993. p53
sweeps through cancer research. Science
262:1958–1961. p53 was discovered in
1979, but it was 10 years before scientists
began to uncover its importance.
Erlich, H. A., D. Gelfand, and J. J. Sninsky. 1991.
Recent advances in the polymerase chain
reaction. Science 252:1643–1651. A review
of recent developments in methods and
applications of the PCR.
Friend, S. 1994. p53: a glimpse at the puppet
behind the shadow play. Science
265:334–335. A short summary of the crucial
roles of p53 protein and how mutations
in the gene coding for it lead to inactivation.
Hall, A. 1994. A biochemical function for Ras—
at last. Science 264:1413–1414. Ras protein
is an enzyme in a signal transduction cascade
stimulating a cell to divide.
Hieter, P., and M. Boguski. 1997. Functional
genomics: it’s all how you read it. Science
278:601–602. An explanation of functional
Klug, W. S. 1991. Concepts of genetics, ed. 3.
New York, Macmillan Publishing Company. A shorter text.
Koshland, D. E., Jr. 1989. The engineering of
species. Science 244:1233. This is the lead
editorial in an issue of the journal containing
several reviews on genetic engineering.
Mange, E. J., and A. P. Mange. 1999. Basic
human genetics, ed. 2 Sunderland, Massachusetts,
Sinauer Associates. A readable,
introductory text concentrating on the
genetics of the animal species of greatest
concern to most of us.
Marx, J. 1994. Oncogenes reach a milestone.
Science 266:1942–1944. Research on oncogenes
has helped us understand many normal
Mullikin, J. C., and A. A. McMurray. 1999.
Sequencing the genome, fast. Science
283:1867–1868. A report from the Sanger
Centre in England on their schedule for
sequencing the human genome.
Mullis, K. B. 1990. The unusual origin of the
polymerase chain reaction. Sci. Am.
262:56–65 (Apr.). How the author had the
idea for the simple production of unlimited
copies of DNA while driving through the
mountains of California.
Russell, P. J. 1992. Genetics, ed. 3. New York,
HarperCollins Publishers. Popular general
Schuler, G. D., and 113 others. 1996. A gene
map of the human genome. Science
274:540–546. More than 16,000 human
genes had been mapped when this paper
was published, representing perhaps onefifth
of the total.
Verma, I. M. 1990. Gene therapy. Sci. Am.
263:68–84 (Nov.). A review of prospects for
treating and preventing genetic diseases by
putting healthy genes into the body.
Weinberg, R. A. 1991. Tumor suppressor genes.
Science 254:1138–1146. How inactivation
of tumor suppressor genes is a step in production