DNA replication and cell cycle
DNA replication and cell cycle
DNA replication in eukaryotic cells is limited to S-phase of the cell cycle (see Physical Basis of Heredity 3. Genetics, Biochemistry and Dynamics of Cell Division). During the S-phase, not only the DNA should be replicated, but also the associated chromosomal histone proteins should be duplicated. The initiation of DNA replication is a prominent landmark in the cell cycle and is, therefore, an important point for exercising control. Further, while in E. coli and other prokaryotes, a solitary origin for DNA replication is found, in eukaryotes, DNA replication needs to be initiated at multiple origins (upto several thousands) in a coordinated manner, though not identically at all origins.